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外文期刊>Pediatric Research
>EFFECT OF INTRATRACHEAL INSTALLATION OF SURFACTANT OH LUNG FUNCTION AND FUNCTIONAL RESIDUAL CAPACITY (FRC) IN PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS)
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EFFECT OF INTRATRACHEAL INSTALLATION OF SURFACTANT OH LUNG FUNCTION AND FUNCTIONAL RESIDUAL CAPACITY (FRC) IN PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS)
To understand the mechanism behind improved oxygenation after surfactant in infants with RDS we analysed changes in lung compliance (CL, ml/cmH2O), lung resistance (RL, cmH2O/l/s/cm), overdistention (C20/C1), FRC (ml) and oxygen need (FiO2). Data were collected serially in nine infants (CurosurfR two, ExosurfR seven) (BW: 1389 ± 540 g) prior to and post surfactant treatment. Lung mechanics were determined by a differential pressure transducer and pneumotachography (PEDSR). FRC was measured by a helium dilution technique (PANDAR) with correction for gas leakage. Ventilator settings (except FiO2) were if possible kept constant during the study. (Data given as mean±SEM).Surfactant significantly increases FRC, while lung compliance and resistance (during mechanical breath) do not improve. The improved oxygenation after surfactant treatment is probably related to increased lung volume.
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机译:为了了解RDS婴儿在使用表面活性剂后改善氧合作用的机制,我们分析了肺顺应性(CL,ml / cmH2O),肺阻力(RL,cmH2O / l / s / cm),过度膨胀(C20 / C1),FRC(毫升)和氧气需求量(FiO2)。在表面活性剂治疗之前和之后,连续收集了9名婴儿(CurosurfR 2,ExosurfR 7)(体重:1389±540 g)的数据。肺力学是由压差传感器和气动描记术(PEDSR)确定的。通过氦稀释技术(PANDAR)测量FRC,并对气体泄漏进行校正。在研究过程中,尽可能将呼吸机设置(FiO2除外)保持恒定。 (数据以平均值±SEM给出)表面活性剂显着增加FRC,而肺顺应性和阻力(机械呼吸过程中)却没有改善。表面活性剂处理后氧合的改善可能与肺容量增加有关。
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