Serum PG 1 levels are raised in children with CP associated gastritis and lower after eradication of the mico-organistn. To assess whether PG 1 levels are related to the severity of antral inflammation we studied 28 chidren 6-15 y ears old (15 males) with superficial chronic antral gastritis: 19 were CP carriers (CP+) and 9 were CP negative (CP-). Antral biopsy specimens were obtained with a pediatric forceps at endoscopy. They were stained with H & E and Giemsa, only those containing muscolaris mucosa were considered. Density of lamina propria inflammatory cell infiltration, and numbers of intraepithelial mononuclear cells and granulocytes were evaluated and graded 0 to 3. Serum PG 1 was determined by RIA. Mean serum PG 1 (± 1SD) was 72±24 ng/ml in CP+ and 45±8 ng/ml in CP-. children (p<.005). Mean total inflammation score was 6 in CP+ and 2.5 in CP-. patients (p<.01), the most significant difference was found in the lamina propria inflammation score (p<.001). Serum PG 1 levels were significantly correlated with total inflammation scores (Spearman's rho = .874, p<.01) in CP+ but not in CP- children.Conclusions: serum PG1 level can be considered an index of severity of antral inflammation in children with CP gastritis.
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