EVALUATION OF A NEW TEST (PHADIATOP) FOR THE SCREENING OF RESPIRATORY ALLERGIC DISEASE IN CHILDREN

摘要

We have studied the sensitivity, specificity, reliability,and predictive value of a nev; method, Phadiatop RIA (Pharmacia, Uppsala), in 98 children (63m, 35f) aged 2-12 yrs (median 6 yrs), with symptoms and signs suggestive of respiratory allergy. Skin tests were done with: House dust, D.Pt., Alternaria T., Lolium, Parietaria. Total IgE were measured with the PRIST (Pharmacia, Uppsala). Specific IgE were measured with the RAST (Pharmacia, Uppsala). Based upon the history, skin tests,and RAST results, 55 children were diagnosed as atopies, 48 of whom were Phadiatop positive. Statistical analysis showed that Phadiatop has an 87% sensitivity, a 100% specificity, a 92% reliability, a 100% positive predictive value, and an 86% negative predictive value. In conclusion, Phadiatop RIA appears to be a simple, reliable,and useful diagnostic tool for the pediatrician and the practitioner for the screening of allergic respiratory disease in children.