Ten healthy children, 3 children with HP, a child with PHP and a child with PPHP were infused with 250 U PTH over 15 min. The renal excretion of cyclic AMP, P, Ca, HCO3, Na and K was measured and compared to 28 adult volunteers. Excretion of healthy children did not differ from the adults' response: Cyclic AMP increased from a mean of 3 to 166nmol/dlGF. P increased from 5 to 16 mg/ dlGF. Ca decreased from 3.2 to 1.8ueq/mg cr.HCO3 from 6 to 170 ueq/mg cr. Na from 137 to 301ueq/mg cr. K from 80 to 197 ueq/mg or. The patients with HP had an exaggerated cyclic AMP, P, HCO3 and K response to PTH. Their Na response was normal. The PHP patient did not increased his cyclic AMP clearance. His P and K responded subnormally and he had a supranormal response of Na and HCO3. The PPHP patient had intermediate response between the normal and the PHP. We conclude that PTH infusion is usefull in the diagnosis of PTH secretion and its renal response. PPHP represents a partial defect in the renal response to PTH.
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