Aortic Intima-Media Thickness, Serum IGF-I, IGFBP-3, and Leptin Levels in Intrauterine Growth-Restricted Newborns of Healthy Mothers

摘要

Neonates with intrauterine growth restriction (IUGR) are associated with reduced concentrations of IGF-I that might contribute to arterial wall thickening. Direct atherogenic effects of leptin have been described. We aimed to investigate the relationship among abdominal aortic intima-media thickness (aIMT), serum IGF-I, IGF binding protein-3, and leptin levels in neonates with IUGR. Abdominal aIMT was measured in 40 term neonates with IUGR and in 40 controls. Mean aIMT was significantly greater in neonates with IUGR (0.45 ± 0.03 mm) than in controls (0.39 ± 0.04 mm, p p = 0.006) and gestational age (β = 0.331, p = 0.022) in a multiple stepwise linear regression analysis. In control neonates, serum IGF-I levels were negatively related to aIMT (β = –0.750, p Abbreviations: AGA, appropriate for gestational age; aIMT, aortic intima-media thickness; cIMT, carotid intima-media thickness; CVD, cardiovascular disease; IGFBP-3, insulin-like growth factor-binding protein-3; IMT, intima-media thickness; IUGR, intrauterine growth restricted; SGA, small for gestational age