|[ldquo]|Cytoviridin(e)|[rdquo]|, A Novel Etiologic Metabolite Characterizing Kawasaki Disease is an Analogue of Human Serum Albumin; Cytotoxic Proteinase Blocking Cyto-chroms and Aggregating Mammalian Thrombocyte

摘要

For simplifying analytic process, the preceded few fractions of the chromato-graphed effluent were put aside and stored for later studies. Their extremely high protein content were conotative of the existence of a polymer deriving most probably from the abve albumin-analogue. For convenience sake, we wish to use “albuminoid” and “globulinoid” respectively. The MW of albuminoid was 66.2 kd; wehreas that of an albumin is 66.0 kd; almost the same values with a similar pI value. Drop of blood-albumin level of patients might be ascribable to the elaboration of albuminoid by the organism, i.e., viridans group streptococci; at least two species take the role, e.g., S. sanguis, S. parasanguis or S. oralis. They usually cooperate for this in situ amino acid and/or peptid synthesis. Thus, the relation between patient (host) and organism (parasite) is conpetitive for depriving these raw materials. Things might be similar in case of globulinoid synthesis; raw materials must be deprived by the organism: rapid improvement of clinical symptoms brought about after gamma-globulin therapy must be due to its genuin complementary efficacy. General views cited above were based on our data on all the stage of molucular evolution, from a precursor peptide through albuminoid up to globulinoid. Data might be applicable to members of similar genom family.