Studies in Danazol (D) treated pubertal boys with gynecomastia (G)

摘要

Diurnal variations of LH,FSH and PRL,values before and after LHRH/TRH,testosterone (T) and estradiol (E2)were determined in 3 pubertal boys with G (>6cm) before(b) and after 200mg D for 90 days. Pubertal development were classified as P4. Results (mean,standard deviations):In conclusion: the reduction of basal gonadotropins, their response to LHRH as well as the reduction of the sleep-related hormone increases suggest that D acts at hypothalamic-pituitary level.The reduction in breast size to 2 cm in diameter in 2 boys may be due to decreased gonadotropins and lowered E2 levels.