78. TOWARD A SUPER-ORAL REHYDRATION SOLUTION (ORS): ENHANCEMENT OF INTESTINAL WATER ABSORPTION BY A POLY-NUTRIENT SOLUTION

摘要

ORS have been widely employed in the treatment of acute diarrhea. However, their optimal formulation is still being debated. Glucose, dipeptides and amino acids are taken up by the intestinal mucosa and thus theoretically stimulate additive water absorption. We therefore compared, in the jejunum of rats perfused in vivo, the absorption of water and ions from two ORS, having identical ionic composition (Na=60 mEq/L) and osmolality (270 mOsm/L), but differing in their nutrient contents. One (G-ORS) only had Glucose 1111 mM), the other had the following composition (in mM): Glucose, 30; L-Lysine, 10; Glutamic acid, 15, L-Phenylalanine, 30; Glycyl-L-Proline, 30. Perfusion was carried out either under controls conditions, or in the presence of the secretagogue 8-Br-cGMP, 0.2 mM. Results (water is μl/min.g, electrolytes are μEq/min.g, means+SE):We conclude that such super-ORS allows a bigger water absorption, particularly in the presence of 8-Br-cGMP. The additional nutritive advantage of nitrogen supplementation makes this solution worth of further testing.