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外文期刊>Pediatric Research
>EFFECTS OF THE SLOW-RELEASE GNRH AGONST DECAPEPTYL-DEPOT |[lpar]|DD|[rpar]| IN CHILDREN WITH CENTRAL PRECOCIOUS PUBERTY |[lpar]|CPP|[rpar]|: PITUTARY-GONADAL FUNCTION, CLINICAL COURSE AND PHARMAKOKINE TICS OF DECAPEPTYL
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EFFECTS OF THE SLOW-RELEASE GNRH AGONST DECAPEPTYL-DEPOT |[lpar]|DD|[rpar]| IN CHILDREN WITH CENTRAL PRECOCIOUS PUBERTY |[lpar]|CPP|[rpar]|: PITUTARY-GONADAL FUNCTION, CLINICAL COURSE AND PHARMAKOKINE TICS OF DECAPEPTYL
In an international multicentre trial of (DD) for treatment of CPP, a total of 76 patients, 68 girls and 8 boys, are presently enrolled. There are 50 (3 boys) naive patients (group I) and 26 (5 boys) who have been treated with either cyproterone acetate or Buserelin before (group I). Basal plasma LH (mlU/ml) decreased from 3.3 ± 0.3 (mean ± SE) and 2.8 ± 0.5 to 2.4 ± 0.3 and 1.6 ± 0.3 after 1 year of therapy in groups I and II, resp. The LH response to GnRH i.v. was signif. (p 2 levels fell signif. from 118 ± 12 to 52 ± 4 pmol/l (p 2. Except of short injection pain (anaesthetic spray helpful), no side effects were seen, we conclude that treatment of CPP with DD, given only every 4 weeks i.m., leads to an effective suppression of the pituitary-gonadal axis without clinical escapes, despite variable and sometimes very low plasma levels of the drug.
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