Detectable IL-8 and IL-10 in Bronchoalveolar Lavage Fluid from Preterm Infants Ventilated for Respiratory Distress Syndrome

摘要

Pro-inflammatory cytokines such as IL-8 play an important role in the inflammatory response to neonatal airway injury. Difficulty in detecting counter-regulatory cytokines such as IL-10 in lavage fluid from preterm infants led to the suggestion that its deficit may be a factor in the etiology of chronic lung disease of prematurity (CLD). The aim of the study was to determine IL-8 and IL-10 concentrations in lavage fluid from preterm infants ventilated for respiratory distress syndrome. Fifty infants p = 0.009). In the same samples, lavage IL-8 concentrations rose significantly over the first postnatal week (p p Abbreviations: APH, antepartum hemorrhage; BAL, bronchoalveolar lavage; CLD, chronic lung disease of prematurity; HRP, horseradish peroxidase; IUGR, intrauterine growth retardation; IVH, intraventricular hemorrhage; IQR, interquartile range; NB-BAL, nonbronchoscopic BAL; PIH, pregnancy-induced hypertension; RDS, respiratory distress syndrome; TMB, 3,3′,5,5′-tetramethylbenzidine