Intracerebral hemorrhage (ICH) possibly induces damage to surrounding cerebral tissue by ischaemia which may cause severe neurological sequelae, mainly cerebral paresis.Methods: We have measured regional CBF within the first days after diagnosis (1-3days) in 6 preterm infants (GA 26-29weeks) with unilateral ICH and in 9 preterm infants (GA 26-32weeks) without ICH using single photon emission computer tomography and 99mTc-HMPAO (Ceretec?) i a dose of 4MBq/kg. We used a 4-head fast rotating gamma camera (Tomomatic 248?) with a spatial resolution of 6×6×8mm.Results: Compared to the control group the flow to the white matter of the affected hemisphere was decreased 37% (p=0.0003, non-paired t-test). The flow to the other regions did not differ significantly but the flow to the grey matter of both hemispheres and to the basal ganglia of the affected hemisphere showed a higher variation than the control group (p<0.01, F-test).Conclusion: Similar to former studies in premature infants we have demonstrated a decreased white matter flow in the affected hemisphere. In contrast, flow abnormalities was seen in the grey matter of both hemispheres. This indicates that ICH may be a part of a more widespred brain damage and; may explain the variation in neurological outcome.
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