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>The Influence of NaCl Supplementation on the Postnatal Development of Urinary Excretion of Noradrenaline, Dopamine, and Serotonin in Premature Infants
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The Influence of NaCl Supplementation on the Postnatal Development of Urinary Excretion of Noradrenaline, Dopamine, and Serotonin in Premature Infants
The present study was designed to investigate the role of noradrenaline (NA), dopamine (DA), and serotonin (5-HT) in the adaptation of premature infants to alterations of sodium balance. Urinary excretion of NA, DA, and 5-HT was measured spectrofluorimetrically in a group of low birth weight premature infants with (group S) and without (group NS) NaCl supplementation. Group S consisted of 10 infants with a birth weight of 1200-1750 g (mean, 1493 g) and gestational age of 28–31 wk (mean, 30.1 wk). Group S included 10 infants with mean birth weight of 1414 g (range, 1150–1600 g) and mean gestational age of 30.5 wk (range, 27–32 wk). Measurements were made on the 7th day and weekly thereafter until the 5th wk of life. NaCl supplementation was given in a dose of 3–5 and 1.5–2.5 mEq/kg/day for 8–21 and 22–35 days, respectively.In group NS, mean urinary excretion of NA and DA increased from 8.6 ± 1 . 5 and 15.8 ± 2.4 μg/day to maximum values of 21.4 ± 5.5 (p p p p < 0.05) were significantly lower in group NS.
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机译：本研究旨在研究去甲肾上腺素（NA），多巴胺（DA）和血清素（5-HT）在使早产儿适应钠平衡变化中的作用。用荧光分光光度法测定了一组低出生体重早产儿（S组）和未添加（NS组）NaCl的尿液中NA，DA和5-HT的排泄。 S组由10名婴儿组成，出生体重为1200至1750 g（平均1493 g），胎龄为28-31 wk（平均30.1 wk）。 S组包括10名婴儿，平均出生体重1414 g（范围1150–1600 g），平均胎龄30.5 wk（范围27–32 wk）。在生命的第7天和之后的每周进行测量，直到生命的第5周。补充NaCl的剂量分别为3–5和1.5–2.5 mEq / kg /天，分别为8–21和22–35天。NS组中，NA和DA的平均尿排泄从8.6±1增加。 NS组的5和15.8±2.4μg/天至最大值21.4±5.5（p p p p <0.05）显着降低。
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