Our purpose was to compare nutrient balance between a PHW and a non-hydrolysed casein/whey (NHCW) formula. Infants (birthweight ≤ 1750 g, gestation ≤ 32 weeks, postnatal age 15 - 59 days) tolerating an enteral intake ≥ 100 cals/kg/d with a weight gain ≥ 15 g/d were studied. Infants were fed both formulas in a balanced random fashion. After a period of 4 days a 48-hour balance was done. Results were analysed using a paired t-test and considered significant at <.05. Nitrogen (N) intake (572 ± 58 v 503 ± 48 mg/kg/d), absorption (490 ± 60 v 453 ± 63) and retention (381 ± 55 v 369 ± 60) were not different. Stool (82 ± 18 v 49 ± 23; p<.01) and urinary (109 ± 76 v 84 ± 38; p,.10) N excretion tended or were greater, while % N absorption (86 ± 4 v 90 ± 6; p<.01), and retention (66 ± 4 v 73 ± 5; p = .06) tended or were less with the PHW formula. Fat and calcium balance were not different. Further analyses indicated that N and fat absorption were affected by postconceptional age and calcium absorption by postnatal age. These findings suggest that N assimilation is not greater with a PHW protein and that immaturity is a confouding variable in the interpretation of balance studies in the preterm infant.
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机译：我们的目的是比较PHW和未水解酪蛋白/乳清（NHCW）配方之间的营养平衡。研究了婴儿（出生体重≤1750 g，妊娠≤32周，出生后15-59天）可耐受肠内摄入≥100 cals / kg / d，体重增加≥15 g / d。婴儿以均衡的随机方式喂食了两个配方食品。经过4天的时间，完成了48小时的平衡。使用配对t检验分析结果，认为显着性<0.05。氮（N）摄入量（572±58 v 503±48 mg / kg / d），吸收（490±60 v 453±63）和保留（381±55 v 369±60）没有差异。粪便（82±18 v 49±23; p <.01）和尿液（109±76 v 84±38; p，.10）N排泄趋于或更大，而N吸收率（％）（86±4 v 90± 6; p <.01），而PHW公式的保留率（66±4 v 73±5; p = .06）趋于或更低。脂肪和钙的平衡没有差异。进一步的分析表明，受孕后的年龄和产后年龄的钙的吸收会影响氮和脂肪的吸收。这些发现表明，PHW蛋白对N的吸收作用不大，在解释早产儿平衡研究中，不成熟是一个令人困惑的变量。
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