55 THE EFFECT OF INTRAVENOUS ANTIBIOTIC THERAPY ON INFLAMMATORY MARKERS IN BRONCHIAL SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS

摘要

In cystic fibrosis, Pseudomonas aeruginosa colonization leads to a progressive destructive chronic bronchitis and despite antibiotic treatment, eradication is not attained and inflammation usually persists. However, in recent years the survival rate of these patients has been markedly improved by repeated, elective i.v. antibiotic treatment. In this study we asked the question how two-weeks antibiotic treatment modified lung (unctions and several inflammatory markers in the bronchial secretions ol seven patients in a total of 12 such treatments.The lung functions (FEV1 and FVC) improved and the number of circulating WBC decreased significantly after each treatment period. In spite of this, no change was observed for the neutrophil chemotactk; activity (NCA) of sputum, or for the mean sputum concentrations of IL-8, and human leukocyte elastase (HLE)activity. The total amount of decreased significantly:In summary, the quality of the spulum remained unchanged, while the quantity decreased significantly together with the general clinical improvement of the patients.