BGP, a protein produced by osteoblasts which has been shown to be a marker of bone growth, was determined by radioimmunoassay in 27 exclusively breast-fed and 6 formula-fed infants at the age of 2 months (mean 62.6 days, SD 2.4) as part of a prospective study of nutrition and growth in normal infants. Knee-heel length was measured with electronic calipers at the age of 1 and 2 months. In breast-fed infants the mean concentration was 274 ng/ml (SD 95) which is ten fold higher than values in 6-10 year old children previously published by us. In formula-fed infants the mean concentration was significantly lower (77 ng/ml, SD 46, p0.05) in knee-heel length and knee-heel length velocity between the breast-fed and the formula-fed infants. The mean knee-heel length was 173 mm (SD 8 mm) and 168 mm (SD 11 mm), respectively. The growth velocity was 0.37 mm/day (SD 0.12) and 0.38 mm/day (SD 0.09), respectively. In conclusion BGP is much higher in breast-fed infants, and this cannot be explained by differences in length or length velocity. Thus BGP should be used with caution as a marker of linear growth in infants. Histomorphometrical parameters of bone formation rates are related to BGP levels in adults. It remains to be seen if bone structure in infants is related to mode of feeding.
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机译:BGP是由成骨细胞产生的一种蛋白质,已被证明是骨生长的标志物,已通过放射免疫分析法在2个月大的27位纯母乳喂养婴儿和6名配方喂养婴儿中进行了放射免疫测定,结果如下:正常婴儿营养与生长前瞻性研究的一部分。在1和2个月大时用电子卡尺测量膝跟长度。在母乳喂养的婴儿中,平均浓度为274 ng / ml(SD 95),比我们先前发布的6-10岁儿童的浓度高十倍。在配方奶喂养的婴儿中,母乳喂养和配方奶喂养的婴儿的膝跟长度和膝跟长度速度的平均浓度显着降低(77 ng / ml,SD 46,p0.05)。平均膝跟长度分别为173毫米(SD 8毫米)和168毫米(SD 11毫米)。生长速度分别为0.37 mm /天(SD 0.12)和0.38 mm /天(SD 0.09)。总之,在母乳喂养的婴儿中BGP更高,这不能用长度或长度速度的差异来解释。因此,应谨慎使用BGP作为婴儿线性生长的标志。成年人骨形成率的组织形态计量学参数与BGP水平有关。婴儿的骨骼结构是否与喂养方式有关尚待观察。
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