VACCINATION OF NEWBORNS FROM HBV-CARRIER MOTHERS IS CONSIDERED AS THE MOST EFFECTIVE METHOD TO PREVENT THE INFANTS TO BECOME CHRONIC CARRIERS OF HBV. SINCE DECEMBER 1985, 35 HEALTHY NEHBORNS FROM HBV-CHRONIC CARRIER MOTHERS HAVE BEEN VACCINATED, AFTER INFORMED CONSENT OF THEIR PARENTS, WITH SK-RIT rec-DNA HEPATITIS B VACCINE: 20 mcg DOSES OF THE VACCINE WERE GIVEN IM IN THE DELTOID REGION AT BIRTH, 1st AND 2nd MONTHS. HBsAG MARKERS WERE ASSAYED IN CORD BLOOD AND AT THE AGES OF 1, 2, 4 AND 6-9 MONTHS.NO ADVERSE REACTIONS WERE RECORDED.SIBLINGS OF THESE NEWBORNS ARE ALSO CHECKED FOR HBV MARKERS AND SERVE AS A HISTORICAL CONTROL GROUP.CONCLUSION: SAFETY AND IMUNOGENICITY OF rec-DNA SK-RIT VACCINE ARE HIGH. A LONGER PERIOD OF OBSERVATION (WITH A BOOSTER INJECTION AT THE AGE OF 12M) IS NEEDED TO EVALUATE THE PROTECTION EFFICACY OF THIS NEW VACCINE.
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