Precocious puberty as a result of ectopic pinealoma with secretion of HCG and AFP has rarely been described in children and adolescents. With these two markers the effectiveness of treatment can be assessed. An 8 1/2 year old boy is described who presented with a 3 months history of precocious puberty. The tumor was located at the posterior part of the third ventricle in the area of the pineal gland. Plasma levels of testosterone ( > 1000 ng/dl), HCG (87.5 ng/ml) and AFP (200 ng/ml) were remarkably elevated before treatment. An 192-iridium implantation was performed since the tumor was inoperable. One year after operation the boy is doing well with a considerably reduced tumor mass and normal HCG and AFP levels. The disadvantage of accelerating bone age needs to be accepted when tumor markers like HCG are used to assess the diagnosis and course of treatment in ectopic pinealoma.
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机译：由于异位松果体瘤伴有HCG和AFP分泌而导致性早熟的现象很少见于儿童和青少年。使用这两个标记可以评估治疗的有效性。描述了一个8 1/2岁的男孩，他有3个月的性早熟史。肿瘤位于松果体区域第三脑室的后部。治疗前血浆睾丸激素（> 1000 ng / dl），HCG（87.5 ng / ml）和AFP（200 ng / ml）显着升高。由于肿瘤无法手术，因此进行了192铱植入。手术后一年，男孩的病情明显好转，HCG和AFP水平正常，表现良好。当使用诸如HCG的肿瘤标记物评估异位松果体瘤的诊断和治疗过程时，必须接受加速骨龄的缺点。
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