The clinical symptoms of the wheezy or obstructive bronchitis and asthma are quite similar. Averagely 10 years after obstructive bronchitis suffered before 2 years of age, the bronchial hyperreactivity /BH/ of children was examined by acetylcholine and histamine challenge, then 2.5 years Later free running /EIA/ /6mins/ and skin prick test /SPT/ were performed with 20 common allergens. Personal and familial anamnestic data have also been registered. 111 children: 33 girls and 78 boys participated in the follow-up. By the time of the 2. follow-up, 7-14 years after the last episode of obstructive bronchitis 2 of them became asthmatic and 4 got hay fever.In contrast to asthmatics no correlation was found between EIA and BH, as well as between BH and SPT positivity, however, significant correlation occurred between SPT positivity and familial allergic disease.
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