The possible compensatory role of human milk lipase in the digestion of dietary fat was examined in a group of very low-birth-weight infants. Fat excretion was studied in 15 preterm infants of gestational age 26 to 33 weeks and birth weight 660 to 1,695 gm. The amount and composition of fecal fat were determined in stools collected for 72 hours. Eight infants were fed Similac 24 LBW exclusively and seven infants were fed a mixture of fresh human milk (40%) and formula (60%). Fat excretion was lower in infants fed a mixture of human milk and formula than in infants fed formula only (4.7% ± 0.50% vs 11.9% ± 1.4% of intake, respectively). Excretion of calcium soaps, when expressed as percent of total fat, was higher in the group fed the human milk-containing diet (18.9% ± 13.5%), than in the group fed formula only (6.8% ± 2.5%); however, the absolute amounts excreted were similar in both groups (65 ± 46 and 45 ± 17 mg/kg/day, respectively). The lower fat excretion in infants fed a mixture of fresh human milk and formula could be related to the lipase present in human milk. These data suggest that human milk lipase probably contributes to the digestion and absorption of dietary fat in the "tiny premature" infant.
展开▼
机译：在一组极低出生体重的婴儿中检查了人乳脂肪酶在膳食脂肪消化中的可能补偿作用。在15个胎龄26至33周，出生体重660至1,695 gm的早产儿中研究了脂肪的排泄。测定收集72小时的粪便中粪便脂肪的量和组成。八名婴儿仅接受Similac 24 LBW喂养，七名婴儿由新鲜人乳（40％）和配方奶（60％）的混合物喂养。喂养人乳和配方奶粉的婴儿的脂肪排泄率低于仅喂养配方奶粉的婴儿（分别为摄入量的4.7％±0.50％和11.9％±1.4％）。钙皂的排泄量（以占总脂肪的百分比表示）在含人乳饮食组（18.9％±13.5％）中高于仅在配方乳喂养组（6.8％±2.5％）中;然而，两组的排泄绝对量相似（分别为65±46和45±17 mg / kg /天）。喂食新鲜人乳和配方奶粉混合物的婴儿中较低的脂肪排泄可能与人乳中存在的脂肪酶有关。这些数据表明人乳脂肪酶可能有助于“小早产”婴儿的饮食脂肪的消化和吸收。
展开▼
