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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Development of a Population-specific Risk Assessment to Predict Elevated Blood Lead Levels in Santa Clara County, California
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Development of a Population-specific Risk Assessment to Predict Elevated Blood Lead Levels in Santa Clara County, California

机译:制定针对特定人群的风险评估,以预测加利福尼亚州圣克拉拉县的血铅水平升高

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Objectives . To determine: (1) the prevalence of a blood lead level (PbB) of 10 μg/dL or greaterand 20 μg/dL or greater among children aged 6 to 72 months attending the Santa Clara County (SCC), California, public clinics, (2) risk factors for elevated PbB in this population, and (3) whether an SCC public clinic population-specific risk-assessment tool and a five-question lead poisoning questionnaire developed by the Centers for Disease Control and Prevention are useful for prospectively identifying children at higher risk for elevated PbB.Methods . We tested for PbB 3630 children aged 6 to 72 months attending SCC public outpatient clinics between August 8, 1991, and September 1, 1992. We then conducted two matched case-control studies. Five local riskfactor questions were combined with the CDC's five-question lead poisoning questionnaire, and from May 1, 1993, to June 30, 1993, we conducted risk assessments on 247 children tested for PbB.Results . Two hundred twenty-two of 3630 children (6.1%) had a PbB of 10 μg/dL or greater. Thirty-nine (1.1%) had a PbB at least 20 μg/dL. Seventy-nine percent of the children screened and 91.0% of the children with PbB at least 10 μg/dL were Hispanic. Twenty percent of Mexican-born Hispanic children had a PbB of 10 μg/dL or greater, versus 7% of U.S.-born Hispanic children. Several factors were associated with elevated PbB among Hispanic children. For identifying children with a PbB of at least 10 μg/dL, the sensitivity and predictive value negative for the CDC's "high risk" definition were 30% and 93%, respectively, whereas for the SCC population-specific high-risk definition, the sensitivity was 90% and the predictive value negative was 98%.Conclusions . Hispanic children attending SCC public clinics have risk factors for elevated PbB that were not included in the CDC's lead poisoning questionnaire. Methods for prioritizing the frequency of lead screening may be improved by combining the CDC's questions with a population-specific risk assessment.
机译:目标。要确定:(1)在加利福尼亚州圣塔克拉拉县(SCC),公共诊所就诊的6至72个月大的儿童中,血铅水平(PbB)的发生率在10μg/ dL或更高,在20μg/ dL或更高, (2)此人群铅中毒升高的危险因素,以及(3)疾病控制与预防中心开发的SCC公共诊所针对人群的风险评估工具和五问题铅中毒调查问卷是否有助于前瞻性鉴定儿童铅升高的较高风险。我们对1991年8月8日至1992年9月1日之间在SCC公共门诊就诊的6至72个月大的PbB 3630儿童进行了测试。然后,我们进行了两个匹配的病例对照研究。五个局部危险因素问题与疾病预防控制中心的五个问题铅中毒问卷相结合,从1993年5月1日至1993年6月30日,我们对247名接受铅检测的儿童进行了风险评估。 3630名儿童中的22名(6.1%)的PbB为10μg/ dL或更高。三十九(1.1%)的PbB至少为20μg/ dL。接受筛查的儿童中有79%是西班牙裔,而铅含量至少为10μg/ dL的PbB儿童中有91.0%。墨西哥出生的西班牙裔儿童中有20%的PbB为10μg/ dL或更高,而美国出生的西班牙裔儿童中PbB为7%。西班牙裔儿童中PbB升高与多种因素有关。对于鉴定铅含量至少为10μg/ dL的儿童,CDC的“高风险”定义的敏感性和预测值为阴性,分别为30%和93%,而对于SCC人群特定的高风险定义,敏感性为90%,阴性预测值为98%。在SCC公共诊所就读的西班牙裔儿童存在铅中毒升高的风险因素,而CDC的铅中毒调查问卷中并未包括这些因素。通过将CDC的问题与针对特定人群的风险评估相结合,可以改善对铅筛选频率进行优先排序的方法。

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