Serum vitamin E levels are reduced in newborn infants. It has been reported that this deficiency is responsible, in part, for the development of anemia in premature infants during the first 6 weeks of life. The efficacy of vitamin E supplementation for the prevention of anemia in premature infants has been studied in a randomized, controlled, and blinded trial. Premature infants whose birth weights were less than 1,500 g were given, by gavage, 25 IU of dl -α-tocopherol or a similar volume of the drug vehicle. Treatment was continued for the first 6 weeks of life. A total of 178 infants were studied. Vitamin E levels were significantly higher in a supplemented group by day 3 and for the remainder of the 6-week period. At 6 weeks of age, there was no significant difference between the supplemented and unsupplemented groups in hemoglobin concentration, reticulocyte and platelet counts, or erythrocyte morphology. It is concluded that there is no evidence to support a policy of administering vitamin E to premature infants to prevent the anemia of prematurity.
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机译：新生婴儿的血清维生素E水平降低。据报道，这种缺乏在一定程度上是导致出生后前6周内早产儿贫血的原因。在一项随机，对照和盲法试验中，研究了补充维生素E预防早产儿贫血的功效。通过管饲法给予25 IU dl-α-生育酚或类似体积的药物媒介物给出生体重小于1,500 g的早产儿。生命的前6周继续治疗。共研究了178名婴儿。补充营养组的维生素E水平在第3天时以及在6周的剩余时间内均显着升高。在6周龄时，补充组和未补充组之间的血红蛋白浓度，网织红细胞和血小板计数或红细胞形态没有显着差异。结论是，没有证据支持对早产儿服用维生素E以预防早产儿贫血的政策。
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