The developmental outcome of 2- and 4-year-old children who had been exposed as infants to chloride-deficient formula was studied. A negative dose-response relationship was demonstrated between use of the formula without additional nutritional supplementation and cognitive outcome as measured by the Bayley Scales of Infant Development (Pearson r = –.55, P = .01) at 2 years of age. A similar negative relationship was demonstrated between this exclusive use of the defective formula and perceptual (Pearson r = –.51, P .05), motor (Pearson r = –.52, P .05), and fine motor (Pearson r = –.75, P .002) ability as measured by the McCarthy Scales of Children's Abilities at 4 years of age. When other known predictors of developmental outcome were taken into account by means of multiple linear regression analyses, exclusive formula use emerged as an important predictor of the children's cognitive functioning at 2 years (model R 2 = .59, P .005) and of quantitative (model R 2 = .58, P .006), perceptual (model R 2 = .63, P .009), and fine motor ability (model R 2 = .74, P .003) at 4 years of age. These data raise concern about the developmental outcome of the children exposed to chloride-deficient formula.
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机译：研究了2岁和4岁儿童的成长结局，这些儿童曾在婴儿中接触过氯缺乏的奶粉。通过使用贝利婴儿发育量表（Pearson r = –.55，P = .01）在2岁时发现，在没有额外营养补充的情况下使用该配方与认知结果之间存在负剂量反应关系。排他性使用有缺陷的公式与知觉（Pearson r = –.51，P <.05），运动（Pearson r = –.52，P <.05）和精细运动（Pearson）之间也表现出相似的负相关关系。 r = –.75，P <.002）能力，通过4岁儿童能力的麦卡锡量表进行了测量。当通过多元线性回归分析考虑其他已知的发育结果预测指标时，排他性公式的使用已成为2岁儿童认知功能的重要预测指标（模型R 2 = .59，P <.005）和4年时的定量（模型R 2 = .58，P <.006），感性（模型R 2 = .63，P <.009）和精细运动能力（模型R 2 = .74，P <.003）年龄。这些数据引起了对暴露于缺乏氯的配方食品的儿童的发育结果的关注。
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