Thirty-five children with chronic hepatitis B were randomly assigned to three groups: group 1 (n = 12), untreated group 2 (n = 11), treated with 1 million units of Interferon gamma per square meter of body surface (MU/m2), three times a week for 24 weeks; and group 3 (n = 12), treated with interferon alfa at a dose of 5 MU/m2, three times a week for 12 weeks followed by 1 MU/m2 of interferon gamma with the same schedule. At the end of the treatment (6th month), hepatitis B virus DNA was negative in 16.5% of the control group, in 9% of the children treated with interferon gamma, and in 16.5% of those treated with interferons alfa and gamma. No child had lost the hepatitis B e antigen by this time. No basal differences in the serum hepatitis B virus DNA concentration among the groups were observed. At follow-up (15th month), viral genome was negative in 25% of the untreated children, in 36% of the group treated with interferon gamma, and in 41.5% of the children who had received interferons alfa and gamma. Hepatitis B e antigen was negative in 25% of the children who belonged to groups 1 and 3 and in 27% of the children treated with interferon gamma only. These data suggest that interferon gamma does not have a powerful antiviral effect on chronic hepatitis B in children. However, it is well tolerated.
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机译：将35例慢性乙型肝炎儿童随机分为三组：第1组（n = 12），未经治疗的第2组（n = 11），每平方米体表使用100万单位干扰素γ（MU / m2 ），每周3次，共24周;第3组（n = 12），以5 MU / m2的剂量使用干扰素α进行治疗，每周3次，共12周，然后以相同的时间表用1 MU / m2的干扰素γ进行治疗。在治疗结束时（第6个月），对照组的16.5％，接受干扰素γ治疗的9％的儿童和接受干扰素α和γ干扰素的16.5％的乙型肝炎病毒DNA阴性。到那时为止，没有儿童丢失乙型肝炎e抗原。各组之间未观察到血清乙型肝炎病毒DNA浓度的基础差异。在随访（第15个月）时，未接受治疗的儿童中有25％，接受干扰素γ治疗的组中有36％和接受阿尔法和γ干扰素的儿童中有41.5％的病毒基因组呈阴性。乙型肝炎e抗原在属于第1组和第3组的儿童中有25％为阴性，而仅接受γ干扰素治疗的儿童中为27％。这些数据表明，干扰素γ对儿童慢性乙型肝炎没有强大的抗病毒作用。但是，它的耐受性很好。
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