Two patients with recurrent bacterial infections associated with dysgammaglobulinemia are reported in whom there was a marked deficiency of 7S gamma-globulins in the presence of elevated concentrations of 19S gamma-globulins. Both patients lacked detectable beta2A-globulins. One of these patients had been known to have congenital agammaglobulinemia and had been followed for a number of years previously. The synthesis of 19S gamma-globulins in this patient was a transient phenomenon associated with renal and hepatic disease, and the ability to synthesize isohemagglutinins, Forssman antibody and anti-typhoid O antibodies. Plasma cells were not seen in the biopsy specimens of liver, spleen and lymph node from one patient, of lymph node from the other, or in bone marrow aspirates from both patients.
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