Utilizing a modification of the 1-stage method of Wolff, the plasma activity of Factor V was estimated in 53 normal newborns during the first week of life. By this method many newborns were found to have low levels of Factor V during the first 2 days of life which rose towards normal by the sixth day. These findings are discussed with reference to previous findings and to the variations in the other clotting factors during the neonatal period.
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