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Advances in Testing Techniques for Digital Microfluidic Biochips

机译:数字微流控生物芯片测试技术的进展

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With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs) in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments. The recently proposed Micro-electrode-dot Array (MEDA)-based DMFBs involve both fluidic and electronic domains in the micro-electrode cell. Thus, the testing techniques for these biochips should be revised in order to ensure proper functionality. This paper describes recent advances in the testing technologies for digital microfluidics biochips, which would serve as a useful platform for developing revisedew testing techniques for MEDA-based biochips. Therefore, the relevancy of these techniques with respect to testing of MEDA-based biochips is analyzed in order to exploit the full potential of these biochips.
机译:随着数字微流控技术的发展,如今,诸如片上DNA分析,即时诊断和自动药物发现等应用已很普遍。在过去的几年中,使用数字微流控生物芯片(DMFB)进行疾病评估和识别目标分子已变得很普遍。这些DMFB在各种医疗应用中使用时,其可靠性至关重要。这些生物芯片中发现的错误主要是由于液滴操作过程中产生的缺陷,芯片降解以及生物测定实验中的不准确性。最近提出的基于微电极点阵列(MEDA)的DMFB涉及微电极单元中的流体域和电子域。因此,应修改这些生物芯片的测试技术,以确保适当的功能。本文介绍了数字微流控生物芯片测试技术的最新进展,这将为开发基于MEDA的生物芯片的修订/新测试技术提供有用的平台。因此,为了开发这些生物芯片的全部潜力,分析了这些技术与基于MEDA的生物芯片的测试的相关性。

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