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A Sensorized Nuss Bar for Patient-Specific Treatment of Pectus Excavatum

机译:带传感器的坚果棒,用于患者专用的念珠菌治疗

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Pectus Excavatum is an anatomical deformation characterized by a depression of the anterior chest wall. Nuss technique (representing the current clinical golden standard) consists in the introduction of a corrective metal bar, in order to raise the sternum in its anatomic natural position. Nowadays, the bar plays purely a mechanical/corrective action and is kept implanted for about three years, supporting up to a maximum force of 250 N. Our study aims at optimizing the procedure of correction, in terms of monitoring the bar effect, minimizing the body response, and facilitating the bar removal. The sensorized Nuss bar prototype inserted in a platform for telemedicine described in this article is able to monitor in vitro pressure data variations, with more than 150 discrete measurements during the operating period. This behavior is promising for future clinical applications, in which the device could be exploited to monitor the forces at work, thus, providing a customized therapeutic protocol, which in turn may optimize the period of implant. The sensorized bar was also provided with a polymeric coating, able to influence human dermal fibroblast behavior in vitro. This highlights the possibility to minimize, in future in vivo applications, tissue fibrotic responses.
机译:Pectus Excavatum是一种解剖学变形,其特征是前胸壁凹陷。努斯技术(代表当前的临床黄金标准)在于引入矫正金属棒,以使胸骨处于其解剖自然位置。如今,钢筋仅起到机械/矫正作用,并被植入约三年,最大支持力为250N。我们的研究旨在优化矫正程序,从监测钢筋效果,最大程度地减少身体的反应,并促进去除酒吧。这篇文章中介绍的将感应式Nuss bar原型插入远程医疗平台中,能够监视体外压力数据变化,在操作期间进行150多次离散测量。这种行为对于未来的临床应用是有前途的,在该临床应用中,可以利用该设备监视工作中的作用力,从而提供定制的治疗方案,从而可以优化植入时间。感测棒还设有聚合物涂层,能够在体外影响人类皮肤成纤维细胞的行为。这突出了在将来的体内应用中使组织纤维化反应最小化的可能性。

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