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首页> 外文期刊>Sensors >Cyclodextrin Derivatives as Chiral Supramolecular Receptors for Enantioselective Sensing
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Cyclodextrin Derivatives as Chiral Supramolecular Receptors for Enantioselective Sensing

机译:环糊精衍生物作为手性超分子受体的对映体选择性传感。

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摘要

In view of the chiral nature of many bio-molecules (and all bio-macromolecules), most of therapeutically active compounds which target these molecules need to be chiral and “good handed” to be effective. In addition to asymmetric synthetic and separation methodologies, enantioselective chemical sensors, able to distinguish between two enantiomers of the same molecule, are of relevance. In order to design these sensing tools, two major classes of enantioselective layers have been developed. The first is based on molecularly imprinted polymers which are produced (polymerized) in the presence of their target, thus the polymeric material keep in “memory” the size and the shape of this molecule and the system could be used for sensing (not reviewed here). The second approach makes use of sensitive layers containing chiral macrocyclic receptors able of stereoselective molecular recognition; these receptors are mainly based on cyclodextrins. In this contribution, are reviewed achievements in the use of native or chemically modified cyclodextrins for chiral sensing purposes (at interfaces). Potentialities of other chiral macrocycles based on calixarenes, calix-resorcinarenes or crown-ethers as supramolecular receptors for enantioselective sensing are discussed.
机译:考虑到许多生物分子(以及所有生物大分子)的手性,大多数靶向这些分子的治疗活性化合物都需要手性和“好手”才能有效。除了不对称合成和分离方法外,能够区分同一分子的两个对映异构体的对映选择性化学传感器也很重要。为了设计这些传感工具,已经开发出两大类对映选择性层。第一种是基于分子印迹的聚合物,该聚合物在靶分子的存在下产生(聚合),因此聚合材料将这种分子的大小和形状保留在“内存”中,并且该系统可用于传感(此处未作评论) )。第二种方法是利用含有手性大环受体的敏感层,它们能够进行立体选择性分子识别。这些受体主要基于环糊精。在此贡献中,综述了将天然或化学修饰的环糊精用于手性感测目的(在界面上)的成就。讨论了基于杯芳烃,杯芳烃-间苯二芳烃或冠醚作为超分子受体的其他手性大环化合物的对映选择性传感的潜力。

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