Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM – 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors.
展开▼
机译:循环伏安法(CV)和计时电流法(CA)已用于在Britton-Robinson缓冲溶液中的硼掺杂金刚石电极(BDDE)上同时感测和确定L-抗坏血酸(AA)和对乙酰氨基酚(AC)。从CV和CA数据获得的两种浓度范围为0.01 mM – 0.1 mM的单组分和双组分溶液中化合物的阳极电流峰值与浓度的校准图证明是线性的,具有很好的相关参数。对于各种情况,涉及AA和AC的单独和同时存在,灵敏度值和RSD为2-3%。与连续一步添加标准品和/或两个特征电位水平下的两个连续和连续计时电流图相关的计时电流技术代表了同时测定实际样品系统(如药物制剂)中AA和AC的可行选择。通过使用数种加法并加上适当的电流校正因数,可确认供应商指示的平均值与计时图非常接近。
展开▼