Formulation and Evaluation of Metformin Engineered Polymeric Nanoparticles for Biomedical Purpose.

摘要

ABSTRACT The current work was intended for the formulation design and characterization of nanoparticles to obtain controlled release of the oral antidiabetic drug, Metformin. It is, however, associated with certain adversities, which can be surmounted by designing novel delivery forms for the drug. The nanoparticles of Metformin were prepared using Ethylcellulose (EC), poly (lactic-co-glycolic acid) (PLGA), poly (methyl methacrylate) (PMMA), and Chitosan as polymers. The formulated nanoparticle.