Acute and Long Term Safety Evaluation of Grape Seed Extract and Zinc Containing Multivitamin-Mineral Nutritional Food Supplement in Rodents.

摘要

ABSTRACT To study the acute and sub-chronic toxicity associated with potential Zincovit tablets with grape seed extract among rats and mice. For acute toxicity in adult female Sprague-Dawley rats and Balb-c mice, the Acute Toxicity Class method (OECD 423 guideline) was employed. Animals were observed individually after dosing daily for a total of 14 days. Sub chronic toxicity was investigated in normal control (2% gum acacia, 1 ml/kg) and Zincovit tablets with grape seed extract at 50, 500 and .