Induction of heat shock protein HSPA6 (HSP70B′) upon HSP90 inhibition in cancer cell lines

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Induction of heat shock protein HSPA6 (HSP70B′) upon HSP90 inhibition in cancer cell lines

机译：在癌细胞系中抑制HSP90后诱导热休克蛋白HSPA6（HSP70B'）

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Genome‐widetranscriptprofilingtoelucidateresponsestoHSP90inhibitionrevealedstronginductionofHSPA6inMCF‐7cellstreatedwith17‐AAG.Time‐anddosedependentinductionofHSPA6(confirmedbyqPCRandWesternBlots)occurredalsoupontreatmentwithRadicicol,anotherHSP90inhibitor.HSPA6wasnotdetectableinuntreatedcellsorcellstreatedwithtoxinsthatdonotinhibitHSP90,oruponapplyingoxidativestress.Thus,HSPA6inductionisnotageneralresponsetocytotoxicinsults.ModulationofHSPA6levelsbysiRNA‐mediatedinhibitionorrecombinantexpressiondidnotinfluence17‐AAGmediatedcelldeath.HSPA6inductionasaconsequenceofHSP90inhibitionoccursinvarious(butnotall)celllinesandmaybeamorespecificmarkerforHSP90inhibitionthaninductionofotherHSP70proteins...

机译：基因组widetranscriptprofilingtoelucidateresponsestoHSP90inhibitionrevealedstronginductionofHSPA6inMCF-7cellstreatedwith17-AAG.Time-anddosedependentinductionofHSPA6（confirmedbyqPCRandWesternBlots）occurredalsoupontreatmentwithRadicicol，anotherHSP90inhibitor.HSPA6wasnotdetectableinuntreatedcellsorcellstreatedwithtoxinsthatdonotinhibitHSP90，oruponapplyingoxidativestress.Thus，HSPA6inductionisnotageneralresponsetocytotoxicinsults.ModulationofHSPA6levelsbysiRNA-mediatedinhibitionorrecombinantexpressiondidnotinfluence17-AAGmediatedcelldeath.HSPA6inductionasaconsequenceofHSP90inhibitionoccursinvarious（butnotall）celllinesandmaybeamorespecificmarkerforHSP90inhibitionthaninductionofotherHSP70proteins ...

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《FEBS Letters》 |2015年第13期|共9页
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Induction of heat shock protein HSPA6 (HSP70B′) upon HSP90 inhibition in cancer cell lines

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