Decreases in valosin‐containing protein result in increased levels of tau phosphorylated at Ser262/356

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Decreases in valosin‐containing protein result in increased levels of tau phosphorylated at Ser262/356

机译：含valosin的蛋白质减少导致tau262 / 356磷酸化的tau水平升高

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VCP/p97isamultifunctionalAAA+‐ATPaseinvolvedinvesiclefusion,proteasomaldegradation,andautophagy.ReporteddysfunctionsoftheseprocessesinAlzheimerdisease(AD),alongwiththelinkageofVCP/p97toinclusionbodymyopathywithPaget'sdiseaseandfrontotemporaldementia(IBMPFD)ledustoexaminethepossiblelinkageofVCPtotheAD‐relevantprotein,tau.VCPlevelswerereducedinADbrains,butnotinthecerebralcortexofanADmousemodel,suggestingthatVCPreductionoccursupstreamoftaupathology.GeneticreductionofVCPinaprimaryneuronalmodelledtoincreasesinthelevelsoftauphosphorylatedatSer262/356,indicatingthatVCPmaybeinvolvedinregulatingpost‐translationalprocessingoftauinAD,demonstratingapossiblefunctionallinkagebetweentauandVCP...

机译：VCP / p97isamultifunctionalAAA + -ATPaseinvolvedinvesiclefusion，proteasomaldegradation，andautophagy.ReporteddysfunctionsoftheseprocessesinAlzheimerdisease（AD），alongwiththelinkageofVCP / p97toinclusionbodymyopathywithPaget'sdiseaseandfrontotemporaldementia（IBMPFD）ledustoexaminethepossiblelinkageofVCPtotheAD-relevantprotein，tau.VCPlevelswerereducedinADbrains，butnotinthecerebralcortexofanADmousemodel，suggestingthatVCPreductionoccursupstreamoftaupathology.GeneticreductionofVCPinaprimaryneuronalmodelledtoincreasesinthelevelsoftauphosphorylatedatSer262 / 356，indicatingthatVCPmaybeinvolvedinregulatingpost-translationalprocessingoftauinAD，demonstratingapossiblefunctionallinkagebetweentauandVCP ...

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《FEBS Letters》 |2011年第21期|共6页
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1. Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356. [J] . Dolan PJ, Jin YN, Hwang W, FEBS letters. . 2011,第21期

机译：含valosin的蛋白质减少导致tau262 / 356磷酸化的tau水平升高。
2. S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy [J] . Tomoki Chiku, Motoki Hayashishita, Taro Saito, Neurobiology of Aging: Experimental and Clinical Research . 2018,第期

机译：S6K / P70S6K1通过减少嫁妆剂的TauoPathy果蝇模型中Ser262的Tau磷酸化水平来保护Tau介导的神经变性。
3. Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment. [J] . Buerger K, Teipel SJ, Zinkowski R, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2005,第1a2期

机译：载脂蛋白E epsilon4携带者中CSF磷酸化tau的水平升高，伴有轻度认知障碍。
4. Transforming growth factor β 3 causes decreased HaCaT cell alignment to extracellular matrix proteins Fibronectin, Laminin and Collagen type I as a result of an enhanced migratory phenotype [C] . R.Berends, M. Youseffi, M. Denyer World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：由于迁移表型增强，转化生长因子β3导致HaCaT细胞与细胞外基质蛋白纤连蛋白，层粘连蛋白和I型胶原的排列减少
5. Superficial Zone Chondrocytes Modulate Polyphosphate Levels In Deep Zone Cartilage Which Correlate with Increased Tissue Formation And Decreased Mineralization By Deep Zone Chondrocytes [D] . Bromand, Sadat 2014

机译：浅层软骨细胞调节深区软骨中的多磷酸盐水平，这与组织形成增加和深区软骨细胞矿化减少有关
6. Decreases in Valosin-Containing Protein result in increased levels of tau phosphorylated at Ser262/356 [O] . Philip J. Dolan, Youngnam N. Jin, Woong Hwang, -1

机译：含缬氨酸蛋白质的降低导致在Ser262 / 356在Ser262 / 356中磷酸化水平增加
7. Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356 [O] . Dolan Philip J., Jin Youngnam N., Hwang Woong, 2011

机译：含valosin的蛋白质减少导致tau262 / 356磷酸化的tau水平升高

Decreases in valosin‐containing protein result in increased levels of tau phosphorylated at Ser262/356

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