Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats

摘要

Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats.BackgroundTubular atrophy is a major feature of most renal diseases and is closely associated with loss of renal function. The present study sought to investigate tubular epithelial cell apoptosis in experimental diabetic nephropathy and to explore the role of pro-apoptotic [transforming growth factor- (TGF-) and anti-apoptotic growth factors [epidermal growth factor (EGF)]. The effects of renoprotective therapy with blockade of the renin-angiotensin system (RAS) also were examined.