Microangiopathic injury and augmented PAI-1 in human diabetic nephropathy

摘要

Microangiopathic injury and augmented PAI-1 in human diabetic nephropathy.BackgroundMicrovascular injury and mesangial dysfunction contribute to the pathogenesis of diabetic glomerulosclerosis. We investigated the extent of microvascular injury characterized by fragmented red blood cells (RBCs) in the mesangium of glomeruli in diabetic nephropathy, and its clinicopathologic significance. We also investigated the possible contributions of plasminogen activator inhibitor-1 (PAI-1), which has been implicated in thrombosis and sclerosis, and the novel steroid receptor superfamily member, peroxisome proliferator-activated receptor (PPAR), implicated in monocyte-foamy macrophage transformation in atherosclerosis and improved insulin responsiveness in diabetes.