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Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination

机译:高毒力肺炎克雷伯菌克隆群23的种群基因组学揭示了早期出现和快速的全球传播

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Severe liver abscess infections caused by hypervirulent clonal-group CG23 Klebsiella pneumoniae have been increasingly reported since the mid-1980s. Strains typically possess several virulence factors including an integrative, conjugative element ICEKp encoding the siderophore yersiniabactin and genotoxin colibactin. Here we investigate CG23’s evolutionary history, showing several deep-branching sublineages associated with distinct ICEKp acquisitions. Over 80% of liver abscess isolates belong to sublineage CG23-I, which emerged in ~1928 following acquisition of ICEKp10 (encoding yersiniabactin and colibactin), and then disseminated globally within the human population. CG23-I’s distinguishing feature is the colibactin synthesis locus, which reportedly promotes gut colonisation and metastatic infection in murine models. These data show circulation of CG23 K. pneumoniae decades before the liver abscess epidemic was first recognised, and provide a framework for future epidemiological and experimental studies of hypervirulent K. pneumoniae. To support such studies we present an open access, completely sequenced CG23-I human liver abscess isolate, SGH10.
机译:自1980年代中期以来,越来越多地报道了由高毒力克隆组CG23肺炎克雷伯菌引起的严重肝脓肿感染。菌株通常具有几种毒力因子,包括编码铁载体耶尔森菌素和基因毒素大肠菌素的整合,共轭元件ICEKp。在这里,我们研究了CG23的进化史,显示了与不同的ICEKp收购相关的几个深层分支。超过80%的肝脓肿分离株属于CG23-I子系,该子系于1928年获得ICEKp10(编码耶尔西菌素和大肠菌素)后出现,然后在全球范围内传播。 CG23-I的显着特征是大肠菌素合成基因座,据报道它可促进鼠模型中的肠道定植和转移性感染。这些数据表明,CG23肺炎克雷伯氏菌的流行在肝脓肿流行首次被认识之前就已经存在了数十年,并为以后的高毒肺炎克雷伯菌的流行病学和实验研究提供了框架。为了支持此类研究,我们提出了一种开放获取的,完全测序的CG23-1人肝脓肿分离株SGH10。

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