Variant Salmonella Genomic Island 1 Antibiotic Resistance Gene Cluster in Salmonella enterica Serovar Albany

摘要

Salmonella genomic island 1 (SGI1) contains anantibiotic resistance gene cluster and has been previouslyidentified in multidrug-resistant Salmonella entericaserovars Typhimurium DT104, Agona, and Paratyphi B. Weidentified a variant SGI1 antibiotic-resistance gene clusterin a multidrug-resistant strain of S. enterica serovar Albanyisolated from food fish from Thailand and imported toFrance. In this strain, the streptomycin resistance aadA2gene cassette in one of the SGI1 integrons was replacedby a dfrA1 gene cassette, conferring resistance to trimetho-prim and an open reading frame of unknown function.Thus, this serovar Albany strain represents the fourth S.enterica serovar in which SGI1 has been identified and thefirst SGI1 example where gene cassette replacement tookplace in one of its integron structures. The antibiotic resist-ance gene cluster of serovar Albany strain 7205.00 consti-tutes a new SGI1 variant; we propose a name of SGI1-F