In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR 120 ) in Aspergillus fumigatus cyp51A , Denmark

摘要

We report a fatal aspergillosis case in which STR Af typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A . This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus .