Medical Procedures and Risk for Sporadic Creutzfeldt-Jakob Disease, Japan, 1999–2008

摘要

To elucidate the association between medical proce-dures and sporadic Creutzfeldt-Jakob disease (sCJD), we analyzed medical procedures (any surgical procedure, neu-rosurgery, ophthalmic surgery, and blood transfusion) for patients registered by the CJD Surveillance Committee in Japan during 1999–2008. We conducted an age-stratifi ed case–control study with 753 sCJD patients and 210 con-trols and a study of patients who underwent neurosurgical or ophthalmic surgical procedures at the same hospital. Al-though the control group was relatively small, no evidence was found that prion disease was transmitted through the investigated medical procedures before onset of sCJD. After onset of sCJD, 4.5% of the sCJD patients underwent opera-tions, including neurosurgical for 0.8% and ophthalmic for 1.9%; no special precautions against transmission of prion diseases were taken. Fortunately, we have not identifi ed pa-tients with prion disease attributed to these operations. Our fi ndings indicate that surgical procedures or blood transfu-sion had little effect on the incidence of sCJD