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Ring Vaccination and Smallpox Control

机译:环形疫苗接种和天花控制

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摘要

We present a stochastic model for the spread of small-pox after a small number of index cases are introduced intoa susceptible population. The model describes a branchingprocess for the spread of the infection and the effects ofintervention measures. We discuss scenarios in which ringvaccination of direct contacts of infected persons is suffi-cient to contain an epidemic. Ring vaccination can be suc-cessful if infectious cases are rapidly diagnosed. However,because of the inherent stochastic nature of epidemic out-breaks, both the size and duration of contained outbreaksare highly variable. Intervention requirements depend onthe basic reproduction number (R0), for which different esti-mates exist. When faced with the decision of whether to relyon ring vaccination, the public health community should beaware that an epidemic might take time to subside even foran eventually successful intervention strategy
机译:在将少量索引病例引入易感人群后,我们提出了天花传播的随机模型。该模型描述了感染传播的分支过程以及干预措施的效果。我们讨论了以下场景:感染者直接接触的环行疫苗足以控制流行病。如果迅速诊断出感染病例,则可以成功进行环行疫苗接种。但是,由于流行病具有内在的随机性,因此爆发的规模和持续时间都高度可变。干预要求取决于基本复制数(R0),对此存在不同的估计。当面临是否要进行环行疫苗接种的决定时,公共卫生界应该意识到,即使最终制定出成功的干预策略,流行病也可能需要一段时间才能消退。

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