Drug-resistant Neisseria gonorrhoeae in Michigan

摘要

The increasing prevalence of quinolone-resistantNeisseria gonorrhoeae (QRNG) in the United States is acause for concern. Detecting resistance is complicated bythe widespread use of molecular tests that do not provideisolates for susceptibility testing. The Michigan Departmentof Community Health developed a sentinel surveillanceprogram to detect antimicrobial drug resistance in N. gon-orrhoeae. Sentinel surveillance from 11 laboratories sub-mitted 1,122 isolates for antimicrobial drug susceptibilitytesting and detected 2 clusters of QRNG from January2003 to September 2004. These clusters were epidemio-logically distinct: one involved young, heterosexual youth,and the other involved older men who have sex with men.This finding led to changes in local treatment recommenda-tions that limited spread of resistant strains. Developmentof the sentinel program, collection of data, and epidemio-logic analysis of the clusters are discussed