97 Eradication by induced apoptosis of chemoresistant infiltrating ductal carcinoma (IDC) characterised by HDAC2 overexpression and 5′CpG island hypermethylation of the FHIT, RARb2, BRCA1, APC, p16(CDKN2A), RASSF1A, CDH1(Ecadherin), stratifin, MDG1 and HIC1 oncosuppressor genes after combined treatment consisting of immunochemoconjugate of anti-DNMT1/HDAC2 bispecific F(ab)2-bsAb linked with cleavable disulfide onto vinorelbine (I-VRL)

J.Giannios; E.Michailakis; P.Lambrinos

首页> 外文期刊>European Journal of Cancer Supplements >97 Eradication by induced apoptosis of chemoresistant infiltrating ductal carcinoma (IDC) characterised by HDAC2 overexpression and 5′CpG island hypermethylation of the FHIT, RARb2, BRCA1, APC, p16(CDKN2A), RASSF1A, CDH1(Ecadherin), stratifin, MDG1 and HIC1 oncosuppressor genes after combined treatment consisting of immunochemoconjugate of anti-DNMT1/HDAC2 bispecific F(ab)2-bsAb linked with cleavable disulfide onto vinorelbine (I-VRL)

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97 Eradication by induced apoptosis of chemoresistant infiltrating ductal carcinoma (IDC) characterised by HDAC2 overexpression and 5′CpG island hypermethylation of the FHIT, RARb2, BRCA1, APC, p16(CDKN2A), RASSF1A, CDH1(Ecadherin), stratifin, MDG1 and HIC1 oncosuppressor genes after combined treatment consisting of immunochemoconjugate of anti-DNMT1/HDAC2 bispecific F(ab)2-bsAb linked with cleavable disulfide onto vinorelbine (I-VRL)

机译：97通过诱导凋亡来消除化学耐药性浸润性导管癌（IDC），其特征为FHIT，RARb2，BRCA1，APC，p16（CDKN2A），RASSF1A，CDH1（Ecadherin），stratifin，MDG1和HIC1的HDAC2过表达和5'CpG岛超甲基化组合治疗后的抑癌基因，包括抗DNMT1 / HDAC2双特异性F（ab）2-bsAb与可裂解的二硫键连接到长春瑞滨（I-VRL）的免疫化学缀合物

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《European Journal of Cancer Supplements》 |2004年第8期|共1页
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J.Giannios; E.Michailakis; P.Lambrinos;
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1. 97 Eradication by induced apoptosis of chemoresistant infiltrating ductal carcinoma (IDC) characterised by HDAC2 overexpression and 5′CpG island hypermethylation of the FHIT, RARb2, BRCA1, APC, p16(CDKN2A), RASSF1A, CDH1(Ecadherin), stratifin, MDG1 and HIC1 oncosuppressor genes after combined treatment consisting of immunochemoconjugate of anti-DNMT1/HDAC2 bispecific F(ab)2-bsAb linked with cleavable disulfide onto vinorelbine (I-VRL) [J] . J.Giannios, E.Michailakis, P.Lambrinos European Journal of Cancer Supplements . 2004,第8期

机译：97通过诱导凋亡来消除化学耐药性浸润性导管癌（IDC），其特征为FHIT，RARb2，BRCA1，APC，p16（CDKN2A），RASSF1A，CDH1（Ecadherin），stratifin，MDG1和HIC1的HDAC2过表达和5'CpG岛超甲基化组合治疗后的抑癌基因，包括抗DNMT1 / HDAC2双特异性F（ab）2-bsAb与可裂解的二硫键连接到长春瑞滨（I-VRL）的免疫化学缀合物

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