The Emerging Threat of Bioterrorism

摘要

The threat of bioterrorism focuses attention on overall preparedness to address the challenges posed by new and reemerging infectious diseases. Bioterrorism scenarios illustrate the diversity of disciplines and perspectives required to confront these threats, whether naturally occurring or purposely caused. The need to strengthen existing and develop new partnerships is clear. Since late 1992, a number of large, complex outbreaks have occurred in the United States. These include the epidemic of over 400,000 cases of waterborne cryptosporidiosis in Milwaukee, the outbreak of severe, unexplained acute respiratory disease now known as hantavirus pulmonary syndrome in the Spring of 1993, the nationwide foodborne salmonellosis outbreak caused by contaminated ice cream that accounted for an estimated 250,000 cases in the fall of 1994, and the increasing problems posed by antimicrobial-resistant organisms in community and health-care settings. Epidemics of plague in India, Ebola hemorrhagic fever in Central Africa, avian (H5N1) influenza in Hong Kong, Hendra virus infection in Australia, and Nipah virus infection recently in Malaysia and Singapore required an international response. During the hantavirus, plague, and Ebola investigations, concerns regarding the possibility of bioterrorism were raised early in the investigations, though these concerns were not supported by subsequent findings.