Fatal Monkeypox in Wild-Living Sooty Mangabey, C?te d’Ivoire, 2012

摘要

Among the poxviruses are several species of orthopoxviruses (OPVs) that are pathogenic to humans, including monkeypox virus (MPXV) and variola virus (VARV). MPXV was first discovered in laboratory captive monkeys in Copenhagen in 1958 (1). After the eradication of VARV during the 1970s, MPXV became the highest pathogenic OPV infection in humans. On the basis of epidemiologic and sequence data, strains of MPXV can be assigned to a West African or a Congo Basin clade; viruses from the Congo Basin clade show more pronounced illness, death, viremia, and human-to-human transmission than do strains from the West African clade (2,3).