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Nontuberculous Mycobacteria in Tap Water

机译:自来水中的非结核分枝杆菌

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To the Editor: A recently published study by Falkinham (1) showed that 17 (46%) of 37 households were contaminated with nontuberculous mycobacteria (NTM) of the same species as those found in patients with lung disease and that 7 (41%) of 17 had the same DNA fi ngerprint as the patient. One patient's isolate from sputum matched the isolate found in the shower water. Therefore, the patient's lung disease was likely acquired by inhalation of aerosols while showering. An isolate from another patient matched the isolate found in tap water. If the patient drank the contaminated water, Mycobacteria avium may have reached the lungs by aspiration because 26% of patients with NTM lung disease have been found to experience gastroesophageal re. ux disease (GERD) (2). Even if none of these scenarios was present, however, NTM patient contamination of samples is still likely. Six of the 7 matching households had water heater temperatures <125°C, indicating a negative correlation between NTM growth and temperature. Most M. avium and M. intracellulare are killed in <5 seconds (3) when exposed to 70oC; thus, all NTM species would likely be killed a few seconds after water reached the boiling point
机译:致编者:Falkinham(1)最近发表的一项研究表明,在37个家庭中,有17个(46%)被与结核病患者中发现的细菌相同种类的非结核分枝杆菌(NTM)污染,还有7个(41%) 17位患者中的DNA指纹与患者相同。一名患者的痰液分离株与淋浴水中的分离株相匹配。因此,患者的肺部疾病很可能是在淋浴时吸入气溶胶而获得的。来自另一名患者的分离株与自来水中发现的分离株相匹配。如果患者喝了被污染的水,由于发现26%的NTM肺病患者经历了胃食管再狭窄,禽分枝杆菌可能已经通过抽吸到达了肺部。 ux疾病(GERD)(2)。即使这些情况都不存在,NTM患者仍可能污染样品。 7个匹配的家庭中有6个的热水器温度低于125°C,这表明NTM的增长与温度之间呈负相关。当暴露于70oC时,大多数鸟分枝杆菌和胞内分枝杆菌在<5秒内被杀死(3);因此,所有NTM物种都可能在水达到沸点后几秒钟被杀死

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