The Retina in Alzheimer's Disease: Histomorphometric Analysis of an Ophthalmologic Biomarker

摘要

Purpose : To provide a histopathologic, morphometric analysis of the retina in Alzheimer's disease (AD). Methods : Human postmortem retinas from eight patients with AD (mean age: 80 ± 12.7 years) and from 11 age-matched controls (mean age: 78 ± 16.57 years) were analyzed. The retinas were sampled from the superior quadrant on both the temporal and nasal sides with respect to the optic nerve. Thickness of the inner and outer layers involving the retinal nerve fiber layer (RNFL), retinal ganglion cell layer (RGCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer nuclear layer (ONL) were measured and compared between controls and AD. A total of 16 measurements of retinal thickness were acquired for each layer. Results : RNFL thinning supero-temporally was significant closest to the optic nerve (～35% thickness reduction; P P P P P P P P 0.01). Conclusions : Our study revealed marked thinning in both the inner and outer layers of the retina. These quantified histopathologic findings provide a more comprehensive understanding of the retina in AD than previously reported.