Purpose : We analyzed the progression of nuclear sclerosis based on changes in refractive values after lens-sparing vitrectomy for macular hole (MH) and epiretinal membrane (ERM). Methods : We reviewed the medical records of patients who underwent lens-sparing vitrectomy between September 2011 and May 2015. All procedures were performed by one surgeon using Constellation?? Vision System (Alcon Laboratories, Inc., Fort Worth, TX). We compared refractive changes in 25 eyes with MH (MH group; age, 65.5 ?± 6.7 years) and 23 eyes with ERM (ERM group; age, 66.9 ?± 7.6 years). All patients underwent 20-gauge pars plana vitrectomy that was finished by suturing three ports. Fluida??air exchange was performed during vitrectomy only in the MH group. Results : There was no significant difference in patient age between the two groups (P = 0.059, unpaired t-test). Myopia progression rate (diopter/month) in the MH group after lens-sparing vitrectomy was higher than that in the ERM group (P = 0.039, unpaired t-test). In comparison with the ERM group, the MH group had several characteristics such as a high number of females (P = 0.016, chi-square test), long surgical time (P 0.001, unpaired t-test), and frequent use of a surgical adjuvant (triamcinoline acetonide, P = 0.019; Brilliant blue green, P 0.001; chi-square test). Conclusions : Myopia progression rate is higher in cases of MH compared to that in cases of ERM because of the characteristics of the condition itself, including fluid-air exchange, a high number of females, long surgical time, and frequent use of a surgical adjuvant. This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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