Anterior segment structural analysis with optical coherence tomography in primary congenital glaucoma

摘要

Purpose: To analyse anterior segment structure using anterior segment optical coherence tomography (AS-OCT) in children with primary congenital glaucoma (PCG). Methods: A prospective case-control study was conducted in children with PCG and without glaucoma (control group), followed in Pediatric Ophthalmology Section of Hospital Dona Estef?￠nia, Centro Hospitalar de Lisboa Central. A complete ophthalmologic evaluation and AS-OCT (AC biometry protocol) were done. Results: Twenty-seven eyes (17 children with PCG) and 22 eyes (11 children without glaucoma) were enrolled in this study. In PCG group were detected higher values of anterior chamber (AC) width and central depth (p0,001), larger angle-opening distance at 500 (p0,001) and 750??m (p=0,001), trabecular-iris space area at 500 and 750??m (p0,001) and angle recess area at 500 (p0,001) and 750??m (p=0,001). Iris was singificantly thinner at 500??m from the scleral spur (p=0,011), in the middle of the iris (p0,001) and at the thickest part (p=0,001), and longer (p0,001), in PCG group. Visual acuity (logMAR) and AC width were positively correlated (r=0,688; p0,001). Other features found included iris hypoplasia and anterior displacement. Conclusions: This first study in children with PCG suggests that AS-OCT is relatively easy to acquire, can help in clinical and surgical follow-up and be useful as prognostic factor.