Mycobacterial lipoprotein mediates mycobacterial survival by inhibiting antimicrobial peptide secretion and blocking phagosomal maturation pathway

摘要

Background: Mycobacterial genome codes for several lipoproteins, and constitute a major component of cell wall. Few of these lipoproteins have been characterized, but function of most of them is yet to be ascertained. Here we establish the role of a previously uncharacterized mycobacterial lipoprotein in intracellular survival through Vitamin D receptor signalling and cathelicidin inhibition.