Mechanism of inhibition of biofilms in Candida albicans by phenyl aldehydes and propanoids

摘要

Background: The majority of manifestations of candidiasis are associated with the formation of Candida biofilms that are notoriously resistant to antimicrobial agents and withstand host immune defenses making biofilm-associated infections refractory to conventional antibiotic therapy. This has encouraged the researchers to investigate the mechanisms of biofilm development so that newer and effective anti-biofilm agents, targeting structural complexity of biofilms, could be exploited. Therefore, this study was conducted to investigate biofilm formation in 20 azole-resistant strains of Candida albicans of clinical origin (vaginitis, urinary tract infections and candidemia).